Grief

Suffering, hardship.

Pain of mind arising from misfortune, significant personal loss, bereavement, misconduct of oneself or others, etc.; sorrow; sadness.

"She was worn out from so much grief."

Cause or instance of sorrow or pain; that which afflicts or distresses; trial.

To deliberately harass and annoy or cause grief to other players of a game in order to interfere with their enjoyment of it; especially, to do this as one’s primary activity in the game.